Part:BBa_K4683005

hsa-miR-20b

The concentration of hsa-miR-20b is positively correlated with that of estrogen (Pérez-Cremades et al., 2018). Like the estrogen molecule, miR-20b activates the ERα pathway, regulating the production of CAD suppressors (Pérez-Cremades et al., 2018), making miR-20b an ideal miRNA to target with our rolling circle amplification (RCA) assay. hsa-miR-20b is used as the basis for BBa_K4683006 and BBa_K4683007, the 3' arm for hsa-mir-20b and 5' arm for hsa-mir-20b, and as the target sequence for BBa_K4683008.

References
Pérez-Cremades, D., Mompeón, A., Vidal-Gómez, X., Hermenegildo, C., & Novella, S. (2018, February 6). MIRNA as a new regulatory mechanism of Estrogen Vascular Action. International journal of molecular sciences. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855695/#B24-ijms-19-00473

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]